Table 4 Multivariate analysis for OS and CSS in training cohort
Cetegory | Overall survival | P | Cancer-specific survival | P |
|---|---|---|---|---|
Hazard Ratio (95% CI) | Hazard Ratio (95% CI) | |||
Age(year) | ||||
< 44 | Reference | Reference | ||
44–67 | 1.372 (1.051–1.790) | 0.019 | 1.285 (0.964–1.713) | 0.086 |
> 67 | 1.738 (1.209–2.498) | 0.002 | 1.659 (1.091–2.524) | 0.018 |
Year at diagnosis | ||||
2004–2009 | Reference | NI | ||
2010–2015 | 1.081 (0.864–1.353) | 0.492 | NI | NI |
Marital status | ||||
Married | Reference | Reference | ||
Single | 1.043 (0.816–1.332) | 0.738 | 1.104 (0.846–1.440) | 0.464 |
Other | 1.207 (0.861–1.691) | 0.274 | 0.916 (0.608–1.381) | 0.677 |
Gradea | ||||
Low | Reference | Reference | ||
High | 1.749 (0.912–3.356) | 0.092 | 1.501 (0.753–2.989) | 0.248 |
Stage | ||||
I | Reference | Reference | ||
II | 1.630 | 0.002 | 1.545 (1.081–2.209) | 0.016 |
III | 2.256 | < 0.001 | 2.403 (1.665–3.467) | < 0.001 |
IV | 2.760 | < 0.001 | 2.652 (1.648–4.628) | < 0.00 |
Tumor size | ||||
< 2 cm | Reference | Reference | ||
2–4 cm | 2.487 (1.512–4.092) | < 0.001 | 2.127 (1.213–3.732) | 0.008 |
> 4 cm | 3.104 (1.916–5.028) | < 0.001 | 2.763 (1.609–4.744) | < 0.001 |
Metastasis | ||||
Absent | Reference | Reference | ||
Present | 2.778 (2.151–3.587) | < 0.001 | 3.029 (2.293–4.001) | < 0.001 |
Surgery | ||||
Performed | Reference | Reference | ||
None | 1.173 (0.881–1.561) | 0.274 | 0.955 (0.702–1.298) | 0.769 |
Radiotherapy | ||||
Yes | Reference | Reference | ||
No | 1.083 (0.831–1.410) | 0.556 | 1.224 (0.910–1.648) | 0.180 |
Chemotherapy | ||||
Yes | Reference | Reference | ||
No | 1.979 (1.485–2.637) | < 0.001 | 1.489 (1.059–2.095) | 0.022 |