Table 2 Hematological toxicity according to the CTCAE 5.0
Characteristic | Before PSM | After PSM | ||||||
|---|---|---|---|---|---|---|---|---|
All n = 227 (%) | Double-agent n = 91 (%) | Triple-agent n = 136 (%) | p-value | All n = 140 (%) | Double-agent n = 70 (%) | Triple-agent n = 70 (%) | p-value | |
Overall grade 3/4 hematological toxicity | 130 (57.3) | 47 (51.6) | 83 (61.0) | 0.206 | 75 (53.6) | 33 (47.1) | 42 (60.0) | 0.175 |
Anemia | ||||||||
 Grade 1 | 35 (15.4) | 22 (24.2) | 13 (9.6) | 0.016 | 18 (12.9) | 14 (20.0) | 4 (5.7) | 0.044 |
 Grade 2 | 81 (35.7) | 28 (30.8) | 53 (39.0) | 53 (37.9) | 23 (32.9) | 30 (42.9) | ||
 Grade 3 | 69 (30.4) | 23 (25.3) | 46 (33.8) | 45 (32.1) | 20 (28.6) | 25 (35.7) | ||
 Grade 4 | 24 (10.6) | 8 (8.8) | 16 (11.8) | 11 (7.9) | 4 (5.7) | 7 (10.0) | ||
Neutropenia | ||||||||
 Grade 1 | 30 (13.2) | 12 (13.2) | 18 (13.2) | 0.024 | 20 (14.3) | 9 (12.9) | 11 (15.7) | 0.497 |
 Grade 2 | 68 (30.0) | 31 (34.1) | 37 (27.2) | 50 (35.7) | 27 (38.6) | 23 (32.9) | ||
 Grade 3 | 50 (22.0) | 26 (28.6) | 24 (17.6) | 30 (21.4) | 16 (22.9) | 14 (20.0) | ||
 Grade 4 | 30 (13.2) | 5 (5.5) | 25 (18.4) | 14 (10.0) | 4 (5.7) | 10 (14.3) | ||
FebrileNeutropenia | ||||||||
 Grade 0 | 220 (96.9) | 90 (98.9) | 130 (95.6) | 0.306 | 134 (95.7) | 69 (98.6) | 65 (92.9) | 0.211 |
 Grade 3 | 7 (3.1) | 1 (1.1) | 6 (4.4) | 6 (4.3) | 1 (1.4) | 5 (7.1) | ||
Thrombocytopenia | ||||||||
 Grade 1 | 38 (16.7) | 18 (19.8) | 20 (14.7) | < 0.001 | 24 (17.1) | 15 (21.4) | 9 (12.9) | < 0.001 |
 Grade 2 | 33 (14.5) | 27 (29.7) | 6 (4.4) | 25 (17.9) | 21 (30.0) | 4 (5.7) | ||
 Grade 3 | 18 (7.9) | 10 (11.0) | 8 (5.9) | 9 (6.4) | 6 (8.6) | 3 (4.3) | ||
 Grade 4 | 4 (1.8) | 0 (0.0) | 4 (2.9) | 2 (1.4) | 0 (0.0) | 2 (2.9) | ||
Creatinine elevation | ||||||||
 Grade 1 | 24 (10.6) | 12 (13.2) | 12 (8.8) | 0.606 | 17 (12.1) | 10 (14.3) | 7 (10.0) | 0.260 |
 Grade 2 | 7 (3.1) | 2 (2.2) | 5 (3.7) | 6 (4.3) | 1 (1.4) | 5 (7.1) | ||
 Grade 3 | 1 (0.4) | 0 (0.0) | 1 (0.7) | 1 (0.7) | 0 (0.0) | 1 (1.4) | ||
 Grade 4 | 1 (0.4) | 0 (0.0) | 1 (0.7) | 1 (0.7) | 0 (0.0) | 1 (1.4) | ||
Alanine transaminase elevation | ||||||||
 Grade 1 | 130 (57.3) | 62 (68.1) | 68 (50.0) | 0.007 | 87 (62.1) | 48 (68.6) | 39 (55.7) | 0.253 |
 Grade 2 | 20 (8.8) | 7 (7.7) | 13 (9.6) | 12 (8.6) | 5 (7.1) | 7 (10.0) | ||
 Grade 3 | 19 (8.4) | 5 (5.5) | 14 (10.3) | 10 (7.1) | 4 (5.7) | 6 (8.6) | ||
 Grade 4 | 3 (1.3) | 3 (3.3) | 0 (0.0) | 2 (1.4) | 2 (2.9) | 0 (0.0) | ||