Fig. 7From: The opposing action of stromal cell proenkephalin and stem cell transcription factors in prostate cancer differentiationLineage of prostate cancer cells. In this schematic, the different prostate cancer cell types are identified by AR and NE expression. The progression from AR+NE− luminal-like to AR−NE+ stem-like is through the activation of scTF, which is equivalent to de-differentiation. Stem-like cancer cells respond to stromal factors such as PENK by undergoing differentiation changing from a scTF+B2Mlo phenotype to that of scTF−B2Mhi. The cell types are represented by different LuCaP lines. The AR+NE+ and AR−NE− types represent an intermediate that can become AR−NE+ from losing the AR expression program and gaining the NE program by the former, and gaining the NE program by the latterBack to article page