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Fig. 7 | BMC Cancer

Fig. 7

From: The opposing action of stromal cell proenkephalin and stem cell transcription factors in prostate cancer differentiation

Fig. 7

Lineage of prostate cancer cells. In this schematic, the different prostate cancer cell types are identified by AR and NE expression. The progression from AR+NE luminal-like to ARNE+ stem-like is through the activation of scTF, which is equivalent to de-differentiation. Stem-like cancer cells respond to stromal factors such as PENK by undergoing differentiation changing from a scTF+B2Mlo phenotype to that of scTFB2Mhi. The cell types are represented by different LuCaP lines. The AR+NE+ and ARNE types represent an intermediate that can become ARNE+ from losing the AR expression program and gaining the NE program by the former, and gaining the NE program by the latter

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