Fig. 6

Left panels. STC1 expression pattern. Array signal intensity values (on a gray scale) were retrieved from transcriptome datasets (top) and displayed in a histogram format (bottom). The intensity values were retrieved from Affymetrix microarray datasets archived in our SCGAP Urologic Epithelial Stem Cells Project. The values are the average after clicking coalesce replicates and probesets. Dataset query using this public database is described in ref. 21. The red line shows the low expression of STC1 in cancer cell lines and xenografts. Right panel. Cancer-associated stromal induction of NCCIT. Down-regulation of scTF and up-regulation of B2M can be seen with induction by cancer-associated (CP) stromal cell conditioned media. Unlike normal prostate stromal cells, these CP stromal cells lack expression of PENK but not STC1