Neoadjuvant chemotherapy and radiotherapy followed by resection/ablation in stage IV rectal cancer patients with potentially resectable metastases

Table 4 Univariable and multivariable analysis for progression-free survival

	Univariable analysis		Multivariable analysis
Factor	Hazard ratio	P	Hazard ratio	P
Age (> 60 vs ≤ 60 ^a)	1.15 (0.72, 1.84)	0.553
Sex (M vs F ^a)	1.04 (0.65, 1.67)	0.865
cT category (IV vs II-III ^a)	1.62 (0.62, 2.58)	0.045	0.98 (0.62, 1.54)	0.916
cN category (II vs 0-I ^a)	1.07 (0.94, 1.73)	0.791
CEA (> 5 or ≤ 5 ^a,b)	1.17 (0.71, 1.92)	0.531
CA199 (> 35 or ≤ 35 ^a,c)	1.02 (0.65, 1.61)	0.929
Metastatic organs (Multiple vs single ^a)	1.06 (0.42, 2.64)	0.089
No. of liver metastases (> 5 vs ≤ 5 ^a)	1.25 (0.96, 2.84)	0.008	1.18 (0.30, 2.89)	0.028

^a The control group of multivariate Cox analysis. ^b The normal values for CEA range 0–5 ng/ml. ^c The normal values for CA199 range 0–35 U/ml
Abbreviations: M male, F female, cT category clinical T category, cN category clinical N category, CEA carcinoembryonic antigen, CA199 carbohydrate antigen 19–9

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