Table 1 Clinical and molecular characteristics of the CRC subgroups stratified by peroxisome score and TIM3 expression
n = 1149 | Group I + II (PeroxisomeHigh) n = 574 (50%) | Group III (PerLowTIM3High) n = 263 (23%) | Group IV (PerLowTIM3Low) n = 312 (27%) | p | |
|---|---|---|---|---|---|
Age (years) | |||||
< 65 | 445 | 239 (54%) | 86 (19%) | 120 (27%) | |
≥ 65 | 704 | 335 (48%) | 177 (25%) | 192 (27%) | 0.048 |
Gender | |||||
Female | 526 | 261 (49%) | 119 (23%) | 146 (28%) | |
Male | 623 | 313 (50%) | 144 (23%) | 166 (27%) | 0.913 |
Stage | |||||
I | 133 | 74 (56%) | 18 (14%) | 41 (31%) | |
II | 474 | 253 (53%) | 110 (23%) | 111 (23%) | |
III | 371 | 169 (46% | 94 (25%) | 108 (29%) | |
IV | 147 | 65 (44%) | 37 (25%) | 45 (31%) | 0.020 |
Location | |||||
Left colon, rectum | 549 | 277 (50%) | 114 (21%) | 158 (29%) | |
Right colon | 578 | 146 (25%) | 146 (25%) | 286 (50%) | 0.149 |
Microsatellite | |||||
MSI | 150 | 64 (43%) | 66 (44%) | 20 (13%) | |
MSS | 949 | 480 (51%) | 178 (19%) | 291 (31%) | < 0.001 |
CMS | |||||
CMS1 | 160 | 65 (41%) | 77 (48%) | 18 (11%) | |
CMS2 | 445 | 274 (62%) | 42 (9%) | 129 (29%) | |
CMS3 | 136 | 89 (65%) | 10 (7%) | 37 (27%) | |
CMS4 | 253 | 74 (29%) | 106 (42%) | 73 (29%) | |
Indeterminate | 106 | 54 (51%) | 24 (23%) | 28 (26%) | < 0.001 |
KRAS status | |||||
Mutated | 374 | 192 (51%) | 92 (25%) | 90 (24%) | |
Wild-type | 664 | 314 (47%) | 156 (23%) | 194 (29%) | 0.197 |
BRAF status | |||||
Mutated | 102 | 36 (35%) | 48 (47%) | 18 (18%) | |
Wild-type | 903 | 455 (50%) | 192 (21%) | 256 (28%) | < 0.001 |
TP53 status | |||||
Mutated | 496 | 222 (45%) | 97 (20%) | 177 (36%) | |
Wild-type | 351 | 191 (54%) | 76 (22%) | 84 (24%) | 0.001 |
CIMP | |||||
High | 164 | 64 (39%) | 70 (43%) | 30 (18%) | |
Low | 771 | 420 (54%) | 159 (21%) | 192 (25%) | < 0.001 |