Fig. 6

Genes involved in FAAO can stratify CRC patients similarly with genes in the peroxisome pathway. a Kaplan–Meier curves are plotted for the risk subgroups based on FAAO score and TIM3 expression in TCGA. b The same as a, but for the GSE39582 dataset. c, d Violin plots showing the ESTIMATE tumor purity (c) and the enrichment level of total immune infiltrates (d) for each subgroup based on FAAO stratification in TCGA. e Boxplots showing enrichment levels of CD8 T cells and macrophages for the three subgroups based on FAAO stratification in TCGA. f, g Comparisons of the tumor mutation load (f) and expression of immune checkpoint genes (g) across the three subgroups stratified by FAAO score and TIM3 expression in TCGA. h, i Heatmaps show the correlation between transcriptomic expression patterns of melanoma patients receiving PD1 or CTLA4 inhibitors and CRC subgroups stratified by FAAO score and TIM3 in TCGA (h) and GSE39582 (i). *P < 0.05; **P < 0.01; ***P < 0.001