Landscape of homologous recombination deficiencies in solid tumours: analyses of two independent genomic datasets

BMC Cancer

Table 3 Bi-allelic loss of function in the Foundation Medicine ovarian and breast cancer cohorts

LoF loss of function
^aOne tumour lost a germline but gained a homozygous somatic mutation
^bComposite heterozygous mutations are considered as bi-allelic LoF
^cThe patient with a compound heterozygous LoF had two somatic frameshift mutations
^dOf the five patients with compound heterozygous LoF, four had both germline and somatic mutations and one had two somatic mutations

ISSN: 1471-2407