Table 4 Comparison of outcome measurements across all available time points, from linear mixed models
Measure | Comparison | Estimated marginal mean difference | 95% CI | p-value | Raw mean difference (SD) |
|---|---|---|---|---|---|
EQ-5D-5L Index a | Post vs Pre | 0.06 | [0.03, 0.09] | < 0.001 | 0.06 (0.13) |
EQ-5D-5L VAS a | Post vs Pre | 724.65 | [21.04, 1428.25] | 0.044 | 6.78 (26.17) |
FACIT-Fatigue | Post vs Pre | −3.94 | [−5.83, −2.05] | < 0.001 | −3.88 (7.49) |
Follow-up vs Pre | −5.00 | [−7.03, −2.98] | < 0.001 | −5.00 (9.10) | |
Follow-up vs Post | −1.07 | [−2.97, 2.83] | 0.272 | −1.15 (7.34) | |
BPI | Post vs Pre | − 2.17 | [− 5.77, 1.43] | 0.236 | − 2.07 (15.03) |
Follow-up vs Pre | −6.01 | [−10.13, − 1.90] | 0.004 | − 5.66 (19.89) | |
Follow-up vs Post | −3.84 | [−7.46, −0.22] | 0.038 | −4.30 (15.49) | |
DASS Total b | Post vs Pre | −0.42 | [−0.73, −0.11] | 0.008 | −5.14 (17.05) |
Follow-up vs Pre | −0.92 | [−1.27, − 0.57] | < 0.001 | −8.82 (15.41) | |
Follow-up vs Post | −0.5 | [− 0.81, − 0.19] | 0.002 | − 4.12 (10.46) | |
DASS Depression b | Post vs Pre | − 0.48 | [− 0.71, − 0.24] | < 0.001 | −3.00 (7.58) |
Follow-up vs Pre | − 0.69 | [− 0.96, − 0.43] | < 0.001 | − 3.69 (7.03) | |
Follow-up vs Post | − 0.22 | [−.46, 0.02] | 0.077 | −1.01 (4.17) | |
DASS Anxiety b | Post vs Pre | − 0.13 | [− 0.39, 0.13] | 0.320 | − 0.66 (4.33) |
Follow-up vs Pre | −0.55 | [− 0.82, − 0.28] | < 0.001 | −1.80 (4.10) | |
Follow-up vs Post | − 0.42 | [− 0.68, − 0.16] | 0.001 | − 1.22 (3.16) | |
DASS Stress b | Post vs Pre | −0.19 | [− 0.43, 0.05] | 0.117 | −1.37 (6.92) |
Follow-up vs Pre | −0.55 | [−0.82, − 0.29] | < 0.001 | −3.07 (6.49) | |
Follow-up vs Post | − 0.36 | [− 0.60, − 0.12] | 0.003 | −1.77 (5.37) |