Fig. 2

Kaplan–Meier curves showing the combined effects of (A) perilobular and intralobular fibrosis and (B) perilobular and intralobular fibrosis, acinar atrophy and chronic inflammation. A The overall log-rank (p = 0.001), between no fibrosis and peri- and intralobular fibrosis (p < 0.001) and between perilobular fibrosis and perilobular and intralobular fibrosis (p = 0.072). B The overall log-rank (p = 0.001), a comparison between no fibrosis, acinar athropy or chronic inflammation versus peri- or intralobular fibrosis (p = 0.914), versus fibrosis and atrophy (p = 0.001) or versus fibrosis, acinar atrophy and chronic inflammation (p = 0.001). We used the Bonferroni correction for multiple comparisons, with the decision level set to at p < 0.025 in A and p < 0.017 in B