Fig. 4

ANP32E Expression Levels Associate with FOX Motif Accessibility and Tumor Stage. A-B) Boxplots comparing ANP32E expression by tumor stage, both in all tumors with available stage data (n=73) (A) and in only tumors from groups 2 and 3 (n=59) (B), indicating that late-stage tumors have significantly lower expression of ANP32E. P-values obtained from one-tailed parametric t-tests. * is p<0.01, ** is p<0.001, *** is p<0.0001. C-D) Scatterplots showing correlation of ANP32E expression with tumor's accessibility in signature 2 regions (C) and with tumor's average accessibility in FOX motifs across all accessible peak regions (n=96280) (D), with tumors colored by stage. R denotes Pearson correlation coefficient; p-values from Pearson's product moment correlation coefficient. E-F) GSEA plots depicting gene ontology associations with high and low ANP32E expression levels for all tumors with RNA-seq data in the TCGA-BRCA project (n=1222) (E) and for all tumors excluding Basal-L (n=1110) (F). FDR values and normalized enrichment scores (NES) obtained within GSEA