Fig. 6

Ferroptosis and GO/KEGG pathway enrichment of DEGs. A The different expression genes (DEGs) (|logFC| > 1, FDR < 0.05) resulted from the comparison among three variant risk clusters through the R package edgeR were merged with ferroptosis regulated genes from FerrDb to do the ferroptosis enrichment. B, C Compared to the DEGs between the ‘Middle-risk’ (M-r) and the ‘Low-risk’ groups (L-r), there were more ferroptosis regulated genes enriching in the DEGs between the ‘High-risk’ (H-r) or ‘Middle-risk’ (M-r) and the ‘Low-risk’ groups. Meanwhile, in three types of ferroptosis regulated genes, ferroptosis driver genes were dominant in the results of L-r vs. H-r while ferroptosis marker genes were the main component after the comparison between L-r and M-r. D, E The GO and KEGG pathway enrichment of DEGs (|logFC| > 2, FDR < 0.05) between ‘High-risk’ group and ‘Low-risk’ group. F, G The GO and KEGG pathway enrichment of DEGs (|logFC| > 2, FDR < 0.05) between ‘Middle-risk’ group and ‘Low-risk’ group