Fig. 5

Leukemia’s microenvironment analysis and the response to immune checkpoint inhibitors (ICIs). A The immune enrichment analysis of differential expression genes (DEGs) from the comparison result between ‘High-risk’ group and ‘Low-risk’ group. B The immune enrichment analysis result of DEGs between ‘Middle-risk’ and ‘Low-risk’ group. C-E The variances of the leukemia microenvironment were reflexed in stromal score, immune score and tumor purity powered by ‘ESTIMATE’ algorithm. F, G The specific killing effect of cytotoxic T lymphocytes was evaluated with cytolytic score and inflammatory score. H The HLA expression level differences among three groups were shown. I, J There was no significant difference of the scores of IFN-γ signature or expanded immune signature among three groups which indicated the patients from variant groups had the similar responses to PD-1 blockers