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Fig. 3 | BMC Cancer

Fig. 3

From: Identification of immune subtypes of Ph-neg B-ALL with ferroptosis related genes and the potential implementation of Sorafenib

Fig. 3

Genetic characteristics of 80 Ph-neg B-ALL patients and ferroptosis involvement analysis. A Coordinated mutation network. Their coordinated mutation relationships in three clusters (red: High-risk, blue: Middle-risk, green: Low-risk) and the mutated frequency of each gene (in the form of both node size and dark degree) were revealed. B The heterogeneity of mutations in three clusters was shown in the set-up picture after statistics. C The spectrum of gene mutations in 80 Ph-neg B-ALL patients clustered into three groups. Referred to FerrDb, NRAS, KRAS, FLT3 and CDKN2A were annotated as ferroptosis driver genes (Fe-driver) while TP53 was annotated as a ferroptosis suppressor gene (Fe-suppressor). The rest mutated genes lacked of evidence correlated to ferroptosis were annotated as the genes negatively related to ferroptosis (Fe-negative). D To compare the ferroptosis related gene mutation among three groups, the accumulated mutation counts were divided by sample counts in variant groups separately. The number of Fe-drivers was significantly different between ‘High-risk’ group and ‘Low-risk’ group (P = 0.043)

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