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Table 3 Breast cancer-specific mortality rates by mammography frequency and age at baseline. Multivariable adjusted hazard ratios for breast cancer-specific mortality risk by mammography frequency, stratified by age group and estimated breast cancer risk at baselinea

From: Mammography screening and mortality by risk status in the California teachers study

 

Age at baseline

 

40–49 (n = 31,398)

50–59 (n = 28,342)

60–74 (n = 25,674)

75–85 (n = 8024)

Univariate analysis

Death (N)

rate and

95% CIb

Death (N)

rate and

95% CIb

Death (N)

rate and

95% CIb

Death (N)

rate and

95% CIb

Breast cancer mortality

 Never/Less frequent

30

27 (19, 39)

17

44 (27, 69)

34

104 (73, 144)

11

93 (49, 162)

 Biennial

42

20 (15, 27)

41

35 (26, 47)

73

79 (62, 99)

17

64 (38, 100)

 Annual

53

19 (15, 25)

144

41 (34, 48)

133

45 (37, 53)

40

75 (54, 101)

Multivariable analysis (Never/Less frequent as referent)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

 Never/Less frequent

ref

ref

ref

ref

 Biennial

0.67 (0.42, 1.09)

0.86 (0.48, 1.52)

0.79 (0.52, 1.19)

0.67 (0.31, 1.44)

 Annual

0.65 (0.41, 1.04)

1.03 (0.61, 1.74)

0.44 (0.30, 0.66)***

0.76 (0.38, 1.53)

Multivariable analysis (Biennial as referent group)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

 Never/Less frequent

1.48 (0.92, 2.40)

1.17 (0.66, 2.07)

1.27 (0.84, 1.93)

1.50 (0.70, 3.25)

 Biennial

ref

ref

ref

ref

 Annual

0.97 (0.65, 1.45)

1.21 (0.85, 1.71)

0.56 (0.42, 0.75)***

1.15 (0.65, 2.04)

Stratified multivariable analysisc

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

Among low/average risk participants

 Never/Less frequent

1.56 (0.95, 2.55)

1.24 (0.65, 2.34)

0.94 (0.50, 1.75)

1.30 (0.45, 3.74)

 Biennial

ref

ref

ref

ref

 Annual

0.93 (0.61, 1.44)

1.22 (0.82, 1.82)

0.63 (0.42, 0.93)*

1.19 (0.52, 2.73)

Among high risk participants

 Never/Less frequent

0.62 (0.06, 6.38)

1.13 (0.30, 4.27)

1.63 (0.92, 2.88)

1.74 (0.56, 5.43)

 Biennial

ref

ref

ref

ref

 Annual

0.52 (0.15, 1.78)

0.98 (0.46, 2.09)

0.46 (0.30, 0.71)***

1.21 (0.53, 2.74)

  1. Abbreviations: HR Hazard ratio, CI confidence interval
  2. a Multivariable models adjusted by age at baseline, race/ethnicity, alcohol consumption, smoking, BMI, lifetime physical activity, menopause and hormone therapy status, comorbidity conditions including heart attack, stroke, diabetes and cancer. Different referent groups were used in the overall model
  3. b Breast cancer-specific mortality rate (number of breast cancer-specific deaths per 100,000 person-years)
  4. c High risk participants were those in highest quintile of estimated baseline breast cancer risk as calculated by Gail model; rest of the participants were low/average risk
  5. *p ≤ 0.05, ***p ≤ 0.001
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BMC Cancer

ISSN: 1471-2407

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