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Table 2 Cox proportional hazard analyses of 307 locoregionally advanced nasopharyngeal carcinoma patients

From: Percent change in apparent diffusion coefficient and plasma EBV DNA after induction chemotherapy identifies distinct prognostic response phenotypes in advanced nasopharyngeal carcinoma

Factors

HROS (95%CI)

P Value

HRPFS (95%CI)

P Value

HRDMFS (95%CI)

P Value

HRLRFS (95%CI)

P Value

Pretreatment EBV DNA levela

3.21 (1.58–6.53)

0.001

3.11 (1.85–5.23)

< 0.001

2.55 (1.21–5.35)

0.013

3.14 (1.51–6.54)

0.002

Post-IC EBV DNA levelb

2.50 (1.37–4.54)

0.003

2.41 (1.52–3.80)

< 0.001

2.42 (1.26–4.65)

0.008

2.25 (1.19–4.26)

0.013

Pretreatment ADC valuea

0.89 (0.47–1.70)

0.727

1.42 (0.86–2.33)

0.170

1.08 (0.54–2.15)

0.838

1.83 (0.89–3.79)

0.103

ΔADC%b

0.44 (0.24–0.82)

0.001

0.35 (0.22–0.56)

< 0.001

0.42 (0.21–0.81)

0.01

0.26 (0.12–0.55)

< 0.001

Response phenotypesc

 Early response

reference

0.001

reference

< 0.001

reference

0.001

reference

< 0.001

 Intermediate response

5.50 (1.91–15.82)

0.002

4.80 (2.33–9.88)

< 0.001

3.96 (1.47–10.66)

0.006

4.93 (1.69–14.41)

0.004

 No response

8.52 (2.90–25.09)

< 0.001

8.83 (4.19–18.59)

< 0.001

7.03 (2.58–19.19)

< 0.001

10.50 (3.51–31.45)

< 0.001

  1. Abbreviations: HR Hazard ratio, CI Confidence interval, OS Overall survival, PFS Progression-free survival, DMFS Distant metastasis-free survival, LRFS Locoregional relapse-free survival, ADC Apparent diffusion coefficient, IC Induction chemotherapy, RT Radiotherapy, ΔADC% Percentage change in ADC value after induction chemotherapy; Response phenotypes = response phenotypes based on percentage change in ADC and plasma EBV DNA post IC
  2. aAge, sex, T stage, N stage, smoking, family history, pretreatment EBV DNA level and pretreatment ADC value were included in the Cox regression model
  3. bAge, sex, T stage, N stage, smoking, family history, post-IC EBV DNA level and percentage change in ADC post IC were included in the Cox regression model
  4. cAge, sex, T stage, N stage, smoking, family history and response status were included in the Cox regression model