Fig. 1

IHC analysis of the expression of SGLT-1 and SGLT-2 in PDAC tumour tissue and adjacent normal tissue. A SGLT-1 was predominantly overexpressed in the cytoplasm of tumour cells. B SGLT-1 was also overexpressed on the membrane of tumour cells. C SGLT-1 was positively expressed on islet cells but not in normal pancreatic cells. D The expression of SGLT-1 in tumour cells was significantly higher than that in normal pancreatic cells. E and F SGLT-2 was positively expressed in islet cells but not in pancreatic cancer. G SGLT-1 was positively expressed in islet cells but not in normal pancreatic cells. H Statistical comparison of the expression of SGLT-2 between pancreatic cancer and normal pancreatic ducts and acinar cells. (Red arrow, tumour cell; blue arrow, islet cells; ^**** for P<0.0001; error bar: standard deviation; ns: not significant)