Fig. 6From: Oral administration of cystine and theanine attenuates 5-fluorouracil-induced intestinal mucositis and diarrhea by suppressing both glutathione level decrease and ROS production in the small intestine of mucositis mouse modelInfluence of CT on the antitumor efficacy of antitumor drug in a tumor-bearing mouse model. CT26 murine colon cancer cells (1 × 106) were subcutaneously transplanted into male BALB/c mice. From Day 8 post transplantation, mice were orally administered CT (280 mg/kg) or methyl cellulose (the vehicle for CT) once daily for 10 days. The mice received 5-FU (150 mg / kg, i.p.) on day 10 after transplantation. The data is presented as the mean ± SEM of 6 mice. CT26 group vs CT26 + 5-FU and CT26 group vs CT26 + 5FU + CT group: ** < 0.01. CT26 + 5-FU group vs CT26 + 5-FU + CT group: No significant difference. (Dunnet’s multiple composition test)Back to article page