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Table 3 Multivariate analyses of risks of OS

From: Higher body mass index indicated better overall survival in pancreatic ductal adenocarcinoma patients: a real-world study of 2010 patients

 

Continuous BMI

WHO Model

X-tile Model

aHR

P value

aHR

P value

aHR

P value

Age

1.004 (0.998–1.011)

0.223

1.004 (0.997–1.01)

0.279

1.004 (0.997–1.011)

0.234

Male (female as Ref.)

1.120 (0.992–1.266)

0.068

1.124 (0.995–1.271)

0.060

1.122 (0.993–1.268)

0.064

ALB

1.004 (0.992–1.017)

0.51

1.004 (0.992–1.016)

0.541

1.005 (0.993–1.017)

0.43

FBG

1.018 (0.997–1.039)

0.086

1.017 (0.996–1.038)

0.111

1.018 (0.998–1.039)

0.084

logCA199

1.164 (1.093–1.240)

<0.001

1.161 (1.09–1.236)

<0.001

1.162 (1.091–1.237)

<0.001

TB

1.000 (0.999–1.001)

0.986

1 (0.999–1.001)

0.902

1 (0.999–1.001)

0.899

Biliary drainage (no as Ref.)

1.113 (0.941–1.316)

0.213

1.109 (0.938–1.311)

0.227

1.114 (0.942–1.318)

0.205

ASA Score

 

0.142

 

0.163

 

0.151

 1

Ref.

 

Ref.

 

Ref.

 

 2

0.926 (0.817–1.050)

0.231

0.926 (0.817–1.05)

0.231

0.927 (0.818–1.051)

0.239

 3

1.182 (0.934–1.495)

0.164

1.179 (0.931–1.493)

0.171

1.184 (0.935–1.498)

0.16

 4

1.317 (0.753–2.305)

0.334

1.272 (0.727–2.228)

0.400

1.298 (0.742–2.271)

0.36

Stage

 

<0.001

 

<0.001

 

<0.001

 Ia

Ref.

 

Ref.

 

Ref.

 

 Ib

1.587 (1.210–2.080)

0.001

1.58 (1.205–2.072)

0.001

1.574 (1.2–2.064)

0.001

 IIa

1.704 (1.226–2.370)

0.002

1.681 (1.209–2.337)

0.002

1.691 (1.216–2.351)

0.002

 IIb

2.399 (1.846–3.117)

<0.001

2.384 (1.834–3.098)

<0.001

2.391 (1.84–3.107)

<0.001

 III

3.568 (2.744–4.640)

<0.001

3.542 (2.724–4.607)

<0.001

3.558 (2.736–4.627)

<0.001

 IV

6.478 (4.856–8.641)

<0.001

6.442 (4.831–8.591)

<0.001

6.501 (4.874–8.671)

<0.001

Differentiation

 

<0.001

 

<0.001

 

<0.001

 I

Ref.

 

Ref.

 

Ref.

 

 II

4.642 (0.649–33.205)

0.126

4.725 (0.66–33.815)

0.122

4.762 (0.665–34.092)

0.12

 III

6.444 (0.903–46.008)

0.063

6.562 (0.918–46.882)

0.061

6.637 (0.929–47.436)

0.059

 IV

\

 

\

 

\

\

 Unknown

1.652 (0.147–18.599)

0.684

1.744 (0.155–19.613)

0.652

1.744 (0.155–19.61)

0.652

Chemotherapy

0.458 (0.405–0.518)

<0.001

0.462 (0.408–0.522)

<0.001

0.462 (0.408–0.522)

<0.001

BMI

0.972 (0.953–0.991

0.004

    

BMI Stage

   

0.002

 

0.003

 Underweight

  

Ref.

 

Ref.

 

 Normal

  

0.759 (0.617–0.935)

0.010

0.821 (0.682–0.989)

0.038

 Overweight

  

0.685 (0.555–0.847)

0.000

0.723 (0.597–0.875)

0.001

  1. ALB Albumin, FBG Fasten blood glucose, TB Total bilirubin, aHR Adjusted hazard ratio, Ref Reference