Fig. 2

Hsa_circ_0008434 promotes GC cell proliferation, migration and invasion in vitro. A qRT-PCR was performed to identify the relative mRNA expression level of hsa_circ_0008434 in GES-1, MKN45, MKN28, AGS, SGC7901, and BGC823 cells. B qRT-PCR analysis confirmed the transfection effects of the three siRNAs. C A CCK-8 assay was used to verify the proliferation ability of SGC7901 cells with or without hsa_circ_0008434 knockdown. D A wound healing assay was conducted to explore the migration ability of SGC7901 cells with or without hsa_circ_0008434 knockdown. E Transwell assays were performed to examine the invasion ability of SGC7901 cells with or without hsa_circ_0008434 knockdown. F A colony formation assay was performed to determine the colony formation ability of SGC7901 cells with or without hsa_circ_0008434 knockdown. ^*p < 0.05; ^**p < 0.01; ^***p < 0.001