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Fig. 1 | BMC Cancer

Fig. 1

From: TRAP1 suppresses oral squamous cell carcinoma progression by reducing oxidative phosphorylation metabolism of Cancer-associated fibroblasts

Fig. 1

The proliferation and apoptosis ability of CAFs and NFs. A Comparison of the primary CAFs and NFs (phase-contrast microscope, × 50). B Comparison of the purified CAFs and NFs at passage 3 (phase-contrast microscope, × 100). C CAFs at passage 3, positive staining with α-SMA and Vimentin, negative staining with CK (× 50). D CAFs and NFs seeded in growth medium were enumerated at 12 h, 24 h, 48 h and 72 h. Data are presented as the mean values ± SD of three independent experiments. Statistically significant relationships are indicated by *p < 0.05, *** < 0.01 and ****p < 0.0001 (compared with NFs). E The flow cytometry analysis was used to examine apoptosis of CAFs and NFs, UR was considered as late apoptosis, and LR was considered as early apoptosis, respectively. The apoptosis rate is the sum of early apoptosis rate and late apoptosis rate. Data are presented as the mean values ± SD of three independent experiments. Statistically significant relationships are indicated by ****p < 0.0001 (compared with NFs)

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