Fig. 8
From: The role of AKR1 family in tamoxifen resistant invasive lobular breast cancer based on data mining
Knockdown or overexpression of AKR1C1, AKR1C2 and AKR1C3 significantly affected the sensitivity of breast cancer cells to TAM. a, b, c The protein levels of the three genes in the established TAM-resistant strains were significantly increased (supplement 2). d, e After overexpression or knockdown of AKR1C1, AKR1C2 or AKR1C3, significantly affected the TAM EC50 value of TAM-sensitive (naive) or resistant (Tam-res) breast cancer cells. f, g After overexpression or knockdown of AKR1C1, AKR1C2 or AKR1C3, significantly affected the cell proliferation of TAM-sensitive (naive) or resistant (Tam-res) breast cancer cells. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001