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Table 3 Univariate and multivariate Cox regression for overall survival in ICC patients after curative resection before PSM

From: Prognostic value and predication model of microvascular invasion in patients with intrahepatic cholangiocarcinoma: a multicenter study from China

Variables

Univariate

Multivariate

HR

95% CI

p-value

HR

95% CI

p-value

Age, year

1.114

0.900–1.379

0.319

   

Sex, male vs female

1.065

0.861–1.317

0.563

   

Hepatitis, no vs yes

0.926

0.742–1.156

0.498

   

Child-Pugh grade,

Grade A vs Grade B

1.404

1.122–1.757

0.003

1.394

1.098–1.769

0.006

Total bilirubin, μmol/L

< 20 vs ≥20

1.346

1.089–1.663

0.006

1.320

1.057–1.648

0.014

CA199, U/mL

< 200 vs ≥200

1.066

0.822–1.383

0.630

   

CEA, μg/L < 5 vs ≥5

1.302

1.020–1.660

0.034

1.364

1.060–1.754

0.016

Blood loss, ml

< 800 vs ≥800

1.162

0.890–1.518

0.270

   

Blood transfusion,

no vs yes

1.035

0.771–1.390

0.820

   

Tumor diameter, cm

≤5 vs > 5

1.730

1.377–2.174

< 0.001

1.560

1.236–1.968

< 0.001

Tumor number

single vs multiple

1.614

1.289–2.020

< 0.001

   

Surgical margin width, cm < 1 vs ≥1

0.745

0.588–0.945

0.015

0.777

0.608–0.992

0.043

Satellite nodules

no vs yes

1.689

1.350–2.112

< 0.001

1.487

1.175–1.882

0.001

Laparoscopy

no vs yes

1.074

0.639–1.806

0.786

   

Differentiation

moderate or high vs poor

0.957

0.731–1.254

0.751

   

Major hepatectomy

no vs yes

1.734

1.387–2.169

< 0.001

   

Hepatolith no vs yes

1.325

0.776–2.264

0.303

   

MVI no vs yes

1.636

1.215–2.203

0.001

1.399

1.022–1.916

0.036

Postoperative hospital stay, day < 15 vs ≥15

1.111

0.898–1.374

0.335

   
  1. Abbreviations: ICC Intrahepatic cholangiocarcinoma, PSM Propensity Score Matching, HR Hazard ratio, CI Confidence interval, CA199 Carbohydrate antigen 199, CEA Carcinoembryonic antigen, MVI Microvascular invasion