Fig. 4

IL8 secretion in CD10H HN6 cells is regulated via the ERK signaling pathway. Expression of CD10, p-ERK, and t-ERK in CD10L, CD10H, Mock, and siRNA groups by Western blot (A). Expression of CD10, p-ERK, and t-ERK in DMSO, AG126 Low, and AG126 High groups by Western blot (B). IL8 expression in DMSO, AG126 Low, and AG126 High groups by ELISA (C). p-ERK and t-ERK were evaluated by Western Blot when stimulated with IL8 and between HN6 Mock and HN6 Oe groups (D).