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Fig. 9 | BMC Cancer

Fig. 9

From: Exosomal microRNA-107 reverses chemotherapeutic drug resistance of gastric cancer cells through HMGA2/mTOR/P-gp pathway

Fig. 9

Exosomal miR-107 reversed drug resistance of SGC-7901/5-FU cells by downregulating HMGA2/mTOR/P-gp pathway. The protein expression levels of HMGA2, p-mTOR/mTOR, P-gp (a-c) and corresponding quantitative analysis (d-f) of SCG7901, MGC-803 and SCG7901/5-FU cells treated with or without exosomal inhibitor GW4869 and transfected with miR-107 inhibitor, co-transfected with miRNA-107 inhibitor/siHMGA2 or negative control were determined. The protein expression levels were detected by western blotting analysis using GAPDH as internal control. Cells treated with vehicle, or transfected with control miRNA or siRNA serve as control. Abbreviations: Exo, exosome; DM, DMSO; GW, GW4869; NC, negative control. Data in a-c are the representative of two independent experiments. Statistical significances in d-f were determined using one-way ANOVA followed by Dunnett’s test. **P < 0.01, compared with the respective controls or sensitive cells

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