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Table 2 Stratification analysis of protective genotypes with Wilms tumor susceptibility

From: METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children

Variables

rs1064034 (cases/controls)

AOR (95% CI) a

Pa

rs298982 (cases/controls)

AOR (95% CI) a

Pa

Combined (cases/controls)

AOR (95% CI) a

Pa

TT

TA/AA

GG

GA/AA

0–4

5

Age, month

  ≤ 18

72/243

66/222

1.00 (0.68–1.47)

0.995

105/356

33/109

1.01 (0.65–1.58)

0.971

106/358

32/107

0.99 (0.63–1.56)

0.967

  > 18

144/321

121/412

0.67 (0.50–0.88)

0.005

216/517

49/216

0.56 (0.39–0.79)

0.001

216/517

49/216

0.56 (0.39–0.79)

0.001

Gender

 Females

109/251

80/270

0.68 (0.49–0.95)

0.025

159/394

30/127

0.59 (0.38–0.91)

0.017

159/396

30/125

0.60 (0.39–0.93)

0.022

 Males

107/313

107/364

0.87 (0.64–1.18)

0.371

162/479

52/198

0.78 (0.55–1.11)

0.172

163/479

51/198

0.76 (0.53–1.09)

0.134

Clinical stages

 I

73/564

64/634

0.81 (0.57–1.15)

0.239

111/873

26/325

0.64 (0.41–1.01)

0.053

111/875

26/323

0.65 (0.42–1.02)

0.060

 II

61/564

52/634

0.77 (0.52–1.14)

0.193

88/873

25/325

0.78 (0.49–1.23)

0.285

88/875

25/323

0.79 (0.49–1.25)

0.305

 III

44/564

48/634

0.94 (0.61–1.44)

0.781

74/873

18/325

0.64 (0.38–1.10)

0.105

74/875

18/323

0.65 (0.38–1.10)

0.111

 IV

28/564

17/634

0.53 (0.29–0.98)

0.043

37/873

8/325

0.58 (0.27–1.26)

0.171

38/875

7/323

0.50 (0.22–1.13)

0.095

 I + II

134/564

116/634

0.79 (0.60–1.04)

0.093

199/873

51/325

0.70 (0.50–0.98)

0.037

199/875

51/323

0.71 (0.51–0.99)

0.043

 III + IV

72/564

65/634

0.79 (0.55–1.12)

0.183

111/873

26/325

0.62 (0.40–0.98)

0.039

112/875

25/323

0.60 (0.38–0.94)

0.026

  1. AOR Adjusted odds ratio, CI Confidence interval
  2. aAdjusted for age and gender, omitting the corresponding factor