Fig. 1

Knockout of MMP12 in Apc^Min/+ Mice Prevents Weight and Muscle Loss. A Plots of the body weight of wild-type (WT), Apc^Min/+, Apc^Min/+; MMP12^−/− and MMP12^−/− mice from 5 to 24 weeks (n = 6 per group). B The ratio of inguinal white adipose tissue to body weight (***P < 0.001; **P < 0.01, n = 5). C The ratio of skeletal muscle to body weight (*P < 0.05, n = 5). D Hematoxylin and eosin staining of inguinal white adipose tissue in WT, Apc^Min/+, Apc^Min/+; MMP12^−/− and MMP12^−/− mice at 24 weeks old. Scale bars: 5 μm. E Evaluation of the inguinal white adipose tissue across 4 groups by ImageJ software (40X) (***P < 0.001; **P < 0.01, Each cell area are shown as means ± SD; n = 5 mice per group). F Hematoxylin and eosin staining of muscle in Apc^Min/+ and Apc^Min/+; MMP12^−/− at 24 weeks old. Scale bars: 5 μm. G Evaluation of the cross-sectional area of the gastrocnemius from Apc^Min/+ mice and Apc^Min/+; MMP12^−/− mice by ImageJ software (40X) (*P < 0.05; data are shown as means ± SD; n = 6 mice per group)