Factors | N | Event | Univariate | Multivariate | ||
---|---|---|---|---|---|---|
OR (95%CI) | p-value | OR (95%CI) | p-value | |||
Age | ||||||
  < 65 | 226 | 56 | 1.15 (0.72, 1.81) | 0.561 | – | – |
  ≥ 65 | 188 | 42 | 1 |  |  |  |
Sex | ||||||
 Male | 287 | 66 | 0.89 (0.55, 1.44) | 0.627 | – | – |
 Female | 127 | 32 | 1 |  |  |  |
Smoking history | ||||||
 Never | 142 | 34 | 1.04 (0.60, 1.80) | 0.889 | – | – |
 Ever | 142 | 33 | 1 |  |  |  |
 Unknown | 130 | 31 | 1.03 (0.59, 1.81) | 0.906 | – | – |
History of hypothyroidism | ||||||
 No | 399 | 89 | 1 |  |  |  |
 Yes | 15 | 9 | 5.22 (1.81, 15.07) | 0.002 | 7.21 (2.38, 21.81) | < 0.001 |
Histology Subtype | ||||||
 Squamous | 79 | 21 | 1.21 (0.69, 2.12) | 0.499 | – | – |
 Non-Squamous | 335 | 77 | 1 |  |  |  |
Treatment Setting | ||||||
 Clinical trial | 161 | 53 | 3.17 (1.99, 5.07) | < 0.001 | 3.43 (2.10, 5.60) | < 0.001 |
 Non-clinical trial | 253 | 39 | 1 |  | 1 |  |
Immunotherapy combination | ||||||
 Monotherapy | 322 | 72 | 1 |  | 1 |  |
 ICI + ICI | 19 | 11 | 4.77 (1.85, 12.32) | 0.001 | 5.30 (1.96, 14.33) | 0.001 |
 ICI + Chemotherapy/others | 73 | 15 | 0.90 (0.34, 5.04) | 0.736 | 0.82 (0.42, 1.58) | 0.550 |