Skip to main content

Table 3 Multivariable Logistic Regression Analysis of Risk Factors for Autoimmunitya

From: Association of advanced age and cancer history with autoimmune disease in melanoma patients: a cross-sectional study

Predictor

Unadjusted

Adjusted

OR (95% CI)

p-valueb

OR (95% CI)

p-valueb

Age

 18–34

1.00

 

1.00

 

 35–49

1.43 (1.34–1.52)

< 0.001

1.30 (1.22–1.39)

< 0.001

 50–64

1.27 (1.20–1.35)

< 0.001

1.38 (1.30–1.46)

< 0.001

 65–74

1.27 (1.19–1.35)

< 0.001

1.36 (1.27–1.45)

< 0.001

 75+

1.63 (1.48–1.57)

< 0.001

1.78 (1.67–1.89)

< 0.001

Sexc

 Male

1.00

 

1.00

 

 Female

1.53 (1.48–1.57)

< 0.001

1.53 (1.48–1.57)

< 0.001

Racec

 White, non-Hispanic

1.00

 

1.00

 

 Black, non-Hispanic

1.16 (1.10–1.22)

< 0.001

1.22 (1.16–1.29)

< 0.001

 Hispanic

0.80 (0.74–0.88)

< 0.001

1.04 (0.95–1.14)

1.00

 Asian/Pacific-Islander

1.04 (0.91–1.18)

1.00

1.13 (1.00–1.29)

0.9780

 Native American/Alaskan Native

1.68 (1.05–2.68)

0.529

1.72 (1.07–2.78)

0.4642

 Multiracial

0.76 (0.40–1.44)

1.00

1.02 (0.54–1.95)

1.000

Smoker Statusc

 Never Smoker

1.00

 

1.00

 

 Current or Past Smoker

1.07 (1.03–1.11)

0.015

1.08 (1.03–1.12)

0.005

Cancer History

 No History of Cancerd

1.00

 

1.00

 

 Melanoma Alone

1.55 (1.43–1.69)

< 0.001

1.59 (1.46–1.73)

< 0.001

 Melanoma and Non- Cutaneous Cancer

3.81 (3.41–4.25)

< 0.001

3.22 (2.87–3.61)

< 0.001

 Non-Cutaneous Cancer

3.00 (2.89–3.10)

< 0.001

2.46 (2.37–2.56)

< 0.001

Metastases at Diagnosis

 Metastases Absent

1.00

   

 Metastases Present

2.76 (2.48–3.08)

< 0.001

1.05 (0.94–1.18)

1.000

  1. aGlobal p-value < 0.001; AIC: 146,098
  2. bIndividual p-values are Bonferroni corrected using the total number of comparisons (n = 18)
  3. cData for patients with unknown status not shown but included in model
  4. dIncludes patients with basal and squamous cell skin cancer