Fig. 5

CGRP promoted the clone formation ability of OSCC cells in vitro through its receptorcalcitonin receptor like receptor (CLR). A CGRP promoted clone formation ability of OSCC cells, and blockade of CGRP receptor using CLR inhibitor Rimegepant antagonized the effects of CGRP in both HN6 and Cal27 cells. B Knockdown of CLR using small interfering RNA antagonized the effects of CGRP in both HN6 and Cal27 cells