Fig. 6

Hsa_circ_0043278 inhibits BC cell growth, migration and invasion by sponging miR-455-3p. A qRT–PCR was used to examine the relative expression of miR-455-3p in MDA-MB-231 cells after transfection of the hsa_circ_0043278 overexpression vector and the miR-455-3p mimic, as well as in MCF-7 cells after transfection of hsa_circ_0043278 shRNA and the miR-455-3p inhibitor. B The growth of MDA-MB-231 and MCF-7 cells in each group was analysed by MTT assays. C The migration capacities of MDA-MB-231 and MCF-7 cells in each group were examined by wound healing assays. Scale bar, 200 μm. D and E The migration and invasion abilities of MDA-MB-231 and MCF-7 cells in each group were analysed by Transwell assays. Scale bar, 100 μm. The data are presented as the mean ± standard deviation values (n = 3); * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001