Skip to main content
Fig. 4 | BMC Cancer

Fig. 4

From: Inhibition of matrix stiffness relating integrin β1 signaling pathway inhibits tumor growth in vitro and in hepatocellular cancer xenografts

Fig. 4

Blockade of integrin signals strengthened tumor suppressive effects of chemotherapy. A, B The tumor growth (A) and survival time (B) of SMMC-7721 cells in nude mice, established as indicated, treated with PBS, ADM, GLPG0187, ADM+ GLPG0187 respectively as indicated. (n = 6 per group). The scale bar in H&E staining is 2000 μm. C, D The tumor growth (C) and survival time (D) of SMMC-7721 cells in nude mice, established as indicated, treated with PBS, DDP, GLPG0187, DDP + GLPG0187 respectively as indicated. (n = 6 per group). E, F The tumor growth of SMMC-7721 cells, pre-cultured in tunable PA hydrogels with high stiffness (16 kPa), in nude mice established as indicated, then treated with PBS, ADM, GLPG0187, ADM+ GLPG0187 respectively as indicated. (n = 6 per group). Data represent mean ± SD, *P < 0.05, **P < 0.01 or as indicated

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us