Table 1 Patient characteristics for PDX1 and PDX2 models
Parameters | PDX1 | PDX2 |
|---|---|---|
Sex | Male | Female |
Age (year) | 55 | 85 |
Body mass index | 20 | 15 |
Asbestos exposure | No | No |
Smoking | No | No |
Drinking | Yes | No |
Tumor location | Pleural | Pleural |
Cell types | Epithelioid | Sarcomatoid |
CT scan | Pleural thickening of annular nodules, lumps in the lungs and chest wall | Pleural thickening of annular nodules, chest wall lumps |
Family history of tumor | No | Yes |
Immunohistochemistry | CK(+), Ki-67(+,70%), TTF1(−), CK5/6(+), WT-1(+), CR\Calretinin(+) | TTF1(−), CK(+), EMA(+), Vim(+), CR\Calretinin(+), D2–40(−), CK5/6(−), WT-1(−), NapsinA(−), P63(−), MyoD1(−), Myogenin(−), S-100(+), CAM5.2(+),SOX10(−), HMB45(−), Melan-A(−), CD31(+), CD34(−), SMA(+), Des(−), Ki-67(+,60%) |
Somatic mutation | BAP1(p.Glu200fs), PIK3CA(p.Glu545Lys), PTEN(p.Arg130*), TP53(p.Arg273His) | NA |