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Fig. 3 | BMC Cancer

Fig. 3

From: X-ray repair cross-complementing protein 1 (XRCC1) loss promotes β-lapachone –induced apoptosis in pancreatic cancer cells

Fig. 3

β-lap blocks MiaPaCa2 and BxPC3 cells in S phase and G2/M phase. A. MiaPaCa2 cells, BxCP3 and MiaPaCa2-shXRCC1 cells were treated with β–lap (6 μM, 6 μM and 3 μM, respectively). After 2 h treatment, medium containing β-lap was replaced by normal culture medium and then the DNA content was quantitated at 4 or 24 h posttreatment with β-lap by flow cytometry. B. The percentages of cells occupying G1, S, and G2/M phases of the cell cycle are shown. Results are represented as the mean ± SD from three independent trials. C. The effect of β-lap on the expression of cycle-associated proteins in MiaPaCa2 and BxPC3 cells was detected by Western blot after treatment with 6 μM β-lap for 2 h. β-actin was used as a loading control

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BMC Cancer

ISSN: 1471-2407

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