Fig. 2
Plasma ENT concentration-time profiles and PK parameters of ENT. a Plasma ENT concentration-time profiles in each cohort. Each point represents the mean + S.D. ENT was administered at points of reverse triangle in combination with EXE 25 mg once daily during the shaded time period. b Dose proportionality of PK parameters of ENT. Each point represents individual subject value after the first administration of ENT. Linear regression lines are superimposed with fixing (broken line) and without fixing (solid line) the y-intercept to origin. AUC0–168 area under the plasma concentration-time curve from time 0–168 h, Cmax maximum plasma concentration, ENT entinostat, EXE exemestane, PK pharmacokinetic, S.D. standard deviation