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Table 4 Interleukin-17F functional studies

From: Variable roles of interleukin-17F in different cancers

Cancer Study type Cell lines/animal type Main results Authors
Blood in vitro PBMCs and CD4+ T cells IL-17F triggers NFkB phosphorylation in T and B cells from patients with CLL, but not age-matched healthy controls. Sherry et al. 2015 [24]
Breast in vitro MCF-7 cells IL-17F enhances MCF-7 cell proliferation, migration and invasion via activation of the MAPK/ERK signaling pathway. Chen et al. 2020 [81]
Colorectal in vitro HCT116 cells IL-17F promotes cancer cell migration and invasion by inducing epithelial-mesenchymal transition Chen et al., 2019 [15]
in vitro HCT116 wild-type and IL-17F overexpressing cell clones IL-17F plays an important role in colon cancer development through regulation of cell cycle. This could partially happen through IL-17F effects on p27 and p38. Tong et al. 2014 [82]
in vitro, in vivo ApcMin/+ mice, CRC cell lines (DLD-1 and HT-29) Tumor-infiltrating leukocytes produce large amounts of T helper type IL17-related cytokines, including IL-17F. Individual neutralization of IL-17F does not change the TIL-derived proproliferative effect in CRC cells. De Simone et al., 2014
in vitro, in vivo Cell lines (HCT116, HUVEC), BALB/c nude mice and C57BL/6 mice IL-17F has protective role in colon cancer, possibly by inhibiting tumor angiogenesis. Tong et al. 2012 [20]
Gastric in vitro Gastric cancer cell line (AGS) IL-17F, may contribute to amplification and persistence of inflammatory processes implicated in inflammation-associated cancer through activation of p65 NFkB. Zhou et al. 2007 [83]
Oral in vitro Cell lines (HSC-3, SCC-25, SAS) IL-17F has an antitumorigenic effect through inhibition of the vasculogenic mimicry Almahmoudi et al. 2021 [84]
in vitro Cell lines (HSC-3, SCC-25, HOKs, HUVEC, CAF) IL-17F inhibited cell proliferation and random migration of oral cancer cells and inhibited the endothelial cell tube formation. Almahmoudi et al. 2019 [21]
Liver in vitro, in vivo Cell lines (293 T, SMMC-7721, ECV304), athymic nude mice IL-17F suppresses cancer cell growth via inhibition of tumor angiogenesis. Xie et al. 2010 [85]
Lung in vitro, in vivo Human A549 and murine LL/2 (LLC1) lung cancer cell lines, bone marrow-derived macrophages from C57BL/6 mice. Chicken chorioallantoic membrane (CAM) IL-17A/F does not affect cancer cell viability or glycolytic metabolism in vitro. Conditioned media from IL-17A/F-stimulated macrophages promoted lung cancer cell progression through an increased migration capacity in vitro and enhanced in vivo tumor growth, proliferation and angiogenesis. Ferreira et al. 2020 [86]
in vivo CCSPcre/K-rasG12D mice IL-17F has no effect on lung cancer development in K-ras mutated mouse model. Chang et al. 2014 [87]
Small intestine in vivo ApcMin/+ mice Ablation of IL-17F significantly inhibits spontaneous intestinal tumorigenesis in the small intestine of ApcMin/+ mice. This was associated with decreased IL-1b and Cox-2 expression as well as IL-17 receptor C (IL-17RC) expression Chae et al., 2011 [88]
  1. Abbrevations: CLL = chronic lymphocytic leukemia, CAF = cancer-associated fibroblasts, HOKs = human oral keratinocytes, HUVEC = human umbilical vein endothelial cells, NFkB = Nuclear Factor kappa-light-chain-enhancer of activated B cells, PBMC = peripheral blood mononuclear cell, TIL = tumor-infiltrating leukocyte