From: Variable roles of interleukin-17F in different cancers
Cancer | SNPs | Population (country) | Study size (patients + healthy control) | Effect on patient (p-value) | Authors |
---|---|---|---|---|---|
Bladder | rs763780 | Iran | 180 + 180 | The rs763780 polymorphism was not associated with bladder cancer susceptibility in the Iranian population. | Aslani et al., 2020 [72] |
rs763780 | Poland | 175 + 207 | rs763780 polymorphism was not associated with bladder cancer susceptibility | Krajewski et al. 2020 [73] | |
rs763780 | China (Han) | 301 + 446 | TT genotype and T allele of rs763780 were more common among patients than controls. Rs763780 SNP was associated with bladder cancer development and tumor stage, as well as gender and smoking status of patient. | Zhou et al. 2013 [67] | |
Blood | rs763780 | Egypt | 100 + 100 | IL-17F mutation showed neither correlation with AML susceptibility nor with therapy outcome. | Zayed et al. 2020 [74] |
rs763780 | Egypt | 100 + 100 | IL-17F gene polymorphisms was not associated with AML risk | Elsissy et al. 2019 [50] | |
rs763780 | Poland | 62 + 125 | The rs763780 IL-17F polymorphism was found to be associated with predisposition to AML | Wróbel et al. 2014 [51] | |
Breast | rs763780 | Southern Iran | 192 + 215 | No association between IL-17F polymorphisms and breast cancer susceptibility | Naeimi et al. 2014 [46] |
rs7771511, rs9382084, rs12203582, rs1266828, rs763780 | China (Han) | 491 + 502 | No association between IL-17F polymorphisms and breast cancer susceptibility | Wang et al. 2012 [47] | |
Cervix | rs763780 | China | 352 + 352 | No association between IL-17F polymorphisms and cervical cancer | Cong et al. 2015 [48] |
rs763780, rs9382084, rs1266828 | China | 264 + 264 | No significant association between IL-17F polymorphisms and cancer risk | Lv et al. 2015 [49] | |
rs763780 | China | 311 + 463 | No association between IL-17F polymorphisms and cancer risk or patient clinical characteristics | Quan et al., 2012 [52] | |
Colorectal | rs641701, rs9463772 | Italy | 370 (test set n = 233, validation set n = 137) | rs641701 and rs9463772 were found to be a prognostic markers related to a high risk of LARC disease recurrence, metastasis, and death | Cecchin et al. 2020 [75] |
rs763780 | China | 352 + 433 | IL-17F rs763780 polymorphism was not associated with the risk of CRC | Feng et al. 2019 [53] | |
rs763780 | Korea | 695 + 1846 | Dietary pattern reflecting inflammation was significantly associated with CRC risk. Moreover, this association could be modified according to the IL-17F rs763780 genotype and anatomic site. | Cho et al. 2018 [54] | |
rs763780 | Saudi Arabia | 117 + 100 | No association between IL-17F polymorphisms and CRC risk | Al Obeed et al. 2018 [55] | |
rs763780 | Malaysia | 70 + 80 | No association between IL-17F polymorphisms and CRC risk | Samiei et al. 2018 [56] | |
rs763780 | France | 122 | IL-17F polymorphisms was not associated with OS/PFS | Lereclus et al. 2017 [17] | |
rs763780 | Southern Iran | 202 + 203 | T allele of IL-17F T7488C may be involved in reduced risk of CRC | Nemati et al. 2015 [19] | |
rs763780 | Tunisia | 102 | IL-17F AG + GG genotypes were more frequent in controls than in patients with colon cancer, and IL-17F wild type genotype AA had an impact on OS. | Omrane et al. 2015 [57] | |
Gastric | rs763780 | Korea | 300 + 247 | T allele frequency of IL-17F rs763780 was found to be statistically higher in patients with gastric cancer, compared with healthy controls | Choi et al. 2016 [58] |
rs763780 | China | 153 + 207 | No association was found between IL-17F rs763780 T > C genotype and risk of gastric cancer | Zhao et al. 2016 [59] | |
rs763780 | China | 326 + 326 | No significant positive association was observed with the risk of gastric cancer and IL-17F polymorphisms | Hou et al. 2015 [60] | |
rs763780 | China | 462 + 462 | No significant differences between rs763780 genotypes and gastric cancer risk | Wang et al. 2014 [61] | |
rs763780 | Chile | 147 + 172 | IL-17F polymorphisms was not associated with risk of gastric cancer | Gonzalez-Hormazabali et al. 2014 [63] | |
rs763780 | China | 572 + 572 | rs763780 polymorphism may be associated with risk of developing gastric cancer, particularly among alcohol drinkers. | Gao et al. 2014 | |
rs763780, rs9382084, rs12203582 | China | 293 + 550 | The rs9382084 TT genotype was significantly associated with an increased risk of gastric cancer and has interaction with tobacco smoking on gastric cancer risk. Rs9382084 genetic variants greatly increase risk of non-cardia gastric cancer. No association was found between variants of rs763780 and rs12203582 and gastric cancer risk | Qinghai et al. 2013 [64] | |
rs763780 | China (Han) | 962 + 787 | IL-17F polymorphisms associated with susceptibility to gastric cancer and clinopathological features of it | Wu et al. 2010 [65] | |
rs763780 | Japan | 102 | No significant association between CIHM status and IL-17F (7488 T > C) | Tahara et al. 2010 [66] | |
rs763780 | Japan | 287 + 524 | No significant difference between IL-17F genotypes and risk of gastric cancer | Shibata et al. 2009 [68] | |
Head and neck | rs763780, rs2397084 | China | 182 + 364 | No association between rs763780 and rs2397084 polymorphisms and risk of oral cancer | Hu et al. 2017 |
rs763780, rs2397084 | China | 121 + 103 | Rs2397084, but not rs763780, was associated with OSCC risk, and this was related to tumor stage and differentiation. IL-17F polymorphisms together with smoking and drinking can enhance the risk of OSCC development | Li et al. 2015 [78] | |
Larynx | rs763780 | China | 325 + 325 | IL-17F genotypes and alleles was not associated with risk of laryngeal cancer | Si et al. 2017 [70] |
Liver | rs763780 | China | 155 + 171 | IL-17F rs763780 polymorphisms do not contribute to HBV-related HCC susceptibility independently | Xi et al. 2015 [72] |
Lung | rs763780, rs1266828, rs12203582 | China | 320 + 358 | rs763780 and rs1266828 were not associated with lung cancer risk. Rs12203582 associated with risk of lung cancer, also among smokers. | He et al. 2017 [69] |
rs763780, rs2397084 | Tunisia | 239 + 258 | IL-17F 7488G allele was associated with increased lung cancer risk. IL-17F7383 A/G polymorphism was not associated with lung cancer risk | Kaabachi et al. 2014 [62] | |
Lymphoma | rs763780 | Brazil | 152 + 212 | rs763780 polymorphism increased risks of developing follicular lymphoma. | Assis-Mendonça et al., 2020 [76] |
Pancreas | rs763780 | European and African | 351 (European ancestry n = 294, African ancestry n = 26) | OS was significantly shorter for the rs763780 heterozygotes compared with controls, but this did not hold in the multivariate analysis. | Innocenti et al. 2012 [71] |
Skin | rs763780 | Iran | 200 + 200 | No association of rs763780 gene polymorphisms and risk of BCC | Mohammadipour et al. 2019 [42] |