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Table 3 IL-17F polymorphisms in cancer

From: Variable roles of interleukin-17F in different cancers

Cancer SNPs Population (country) Study size (patients + healthy control) Effect on patient (p-value) Authors
Bladder rs763780 Iran 180 + 180 The rs763780 polymorphism was not associated with bladder cancer susceptibility in the Iranian population. Aslani et al., 2020 [72]
rs763780 Poland 175 + 207 rs763780 polymorphism was not associated with bladder cancer susceptibility Krajewski et al. 2020 [73]
rs763780 China (Han) 301 + 446 TT genotype and T allele of rs763780 were more common among patients than controls. Rs763780 SNP was associated with bladder cancer development and tumor stage, as well as gender and smoking status of patient. Zhou et al. 2013 [67]
Blood rs763780 Egypt 100 + 100 IL-17F mutation showed neither correlation with AML susceptibility nor with therapy outcome. Zayed et al. 2020 [74]
rs763780 Egypt 100 + 100 IL-17F gene polymorphisms was not associated with AML risk Elsissy et al. 2019 [50]
rs763780 Poland 62 + 125 The rs763780 IL-17F polymorphism was found to be associated with predisposition to AML Wróbel et al. 2014 [51]
Breast rs763780 Southern Iran 192 + 215 No association between IL-17F polymorphisms and breast cancer susceptibility Naeimi et al. 2014 [46]
rs7771511, rs9382084, rs12203582, rs1266828, rs763780 China (Han) 491 + 502 No association between IL-17F polymorphisms and breast cancer susceptibility Wang et al. 2012 [47]
Cervix rs763780 China 352 + 352 No association between IL-17F polymorphisms and cervical cancer Cong et al. 2015 [48]
rs763780, rs9382084, rs1266828 China 264 + 264 No significant association between IL-17F polymorphisms and cancer risk Lv et al. 2015 [49]
rs763780 China 311 + 463 No association between IL-17F polymorphisms and cancer risk or patient clinical characteristics Quan et al., 2012 [52]
Colorectal rs641701, rs9463772 Italy 370 (test set n = 233, validation set n = 137) rs641701 and rs9463772 were found to be a prognostic markers related to a high risk of LARC disease recurrence, metastasis, and death Cecchin et al. 2020 [75]
rs763780 China 352 + 433 IL-17F rs763780 polymorphism was not associated with the risk of CRC Feng et al. 2019 [53]
rs763780 Korea 695 + 1846 Dietary pattern reflecting inflammation was significantly associated with CRC risk. Moreover, this association could be modified according to the IL-17F rs763780 genotype and anatomic site. Cho et al. 2018 [54]
rs763780 Saudi Arabia 117 + 100 No association between IL-17F polymorphisms and CRC risk Al Obeed et al. 2018 [55]
rs763780 Malaysia 70 + 80 No association between IL-17F polymorphisms and CRC risk Samiei et al. 2018 [56]
rs763780 France 122 IL-17F polymorphisms was not associated with OS/PFS Lereclus et al. 2017 [17]
rs763780 Southern Iran 202 + 203 T allele of IL-17F T7488C may be involved in reduced risk of CRC Nemati et al. 2015 [19]
rs763780 Tunisia 102 IL-17F AG + GG genotypes were more frequent in controls than in patients with colon cancer, and IL-17F wild type genotype AA had an impact on OS. Omrane et al. 2015 [57]
Gastric rs763780 Korea 300 + 247 T allele frequency of IL-17F rs763780 was found to be statistically higher in patients with gastric cancer, compared with healthy controls Choi et al. 2016 [58]
rs763780 China 153 + 207 No association was found between IL-17F rs763780 T > C genotype and risk of gastric cancer Zhao et al. 2016 [59]
rs763780 China 326 + 326 No significant positive association was observed with the risk of gastric cancer and IL-17F polymorphisms Hou et al. 2015 [60]
rs763780 China 462 + 462 No significant differences between rs763780 genotypes and gastric cancer risk Wang et al. 2014 [61]
rs763780 Chile 147 + 172 IL-17F polymorphisms was not associated with risk of gastric cancer Gonzalez-Hormazabali et al. 2014 [63]
rs763780 China 572 + 572 rs763780 polymorphism may be associated with risk of developing gastric cancer, particularly among alcohol drinkers. Gao et al. 2014
rs763780, rs9382084, rs12203582 China 293 + 550 The rs9382084 TT genotype was significantly associated with an increased risk of gastric cancer and has interaction with tobacco smoking on gastric cancer risk. Rs9382084 genetic variants greatly increase risk of non-cardia gastric cancer. No association was found between variants of rs763780 and rs12203582 and gastric cancer risk Qinghai et al. 2013 [64]
rs763780 China (Han) 962 + 787 IL-17F polymorphisms associated with susceptibility to gastric cancer and clinopathological features of it Wu et al. 2010 [65]
rs763780 Japan 102 No significant association between CIHM status and IL-17F (7488 T > C) Tahara et al. 2010 [66]
rs763780 Japan 287 + 524 No significant difference between IL-17F genotypes and risk of gastric cancer Shibata et al. 2009 [68]
Head and neck rs763780, rs2397084 China 182 + 364 No association between rs763780 and rs2397084 polymorphisms and risk of oral cancer Hu et al. 2017
rs763780, rs2397084 China 121 + 103 Rs2397084, but not rs763780, was associated with OSCC risk, and this was related to tumor stage and differentiation. IL-17F polymorphisms together with smoking and drinking can enhance the risk of OSCC development Li et al. 2015 [78]
Larynx rs763780 China 325 + 325 IL-17F genotypes and alleles was not associated with risk of laryngeal cancer Si et al. 2017 [70]
Liver rs763780 China 155 + 171 IL-17F rs763780 polymorphisms do not contribute to HBV-related HCC susceptibility independently Xi et al. 2015 [72]
Lung rs763780, rs1266828, rs12203582 China 320 + 358 rs763780 and rs1266828 were not associated with lung cancer risk. Rs12203582 associated with risk of lung cancer, also among smokers. He et al. 2017 [69]
rs763780, rs2397084 Tunisia 239 + 258 IL-17F 7488G allele was associated with increased lung cancer risk. IL-17F7383 A/G polymorphism was not associated with lung cancer risk Kaabachi et al. 2014 [62]
Lymphoma rs763780 Brazil 152 + 212 rs763780 polymorphism increased risks of developing follicular lymphoma. Assis-Mendonça et al., 2020 [76]
Pancreas rs763780 European and African 351 (European ancestry n = 294, African ancestry n = 26) OS was significantly shorter for the rs763780 heterozygotes compared with controls, but this did not hold in the multivariate analysis. Innocenti et al. 2012 [71]
Skin rs763780 Iran 200 + 200 No association of rs763780 gene polymorphisms and risk of BCC Mohammadipour et al. 2019 [42]
  1. Abbrevations: AML = acute myeloid leukemia, BCC = basal cell carcinoma, CIHM = CpG island hypermethylation, CRC = colorectal cancer, HBV = hepatitis B virus, HCC = hepatocellular carcinoma, LARC = locally Advanced Rectal Cancer, OS = overall survival, OSCC = oral squamous cell carcinoma, PFS = progression-free survival