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Fig. 2 | BMC Cancer

Fig. 2

From: Cellular retinol binding protein-1 inhibits cancer stemness via upregulating WIF1 to suppress Wnt/β-catenin pathway in hepatocellular carcinoma

Fig. 2

CRBP-1 contributes to the cell growth in vitro and tumorigenicity in vivo of HCC. (A) Western-blot analysis of the expression of endogenous CRBP-1 in HCC cell lines. (B) Cell proliferation analysis of CRBP-1 overexpressed and control PLC/PRF/5 and Huh7 cells. All data shown represent the mean ± SD from three independent experiments. (C) Colony formation analysis of CRBP-1 overexpressed and control PLC/PRF/5 and Huh7 cells. All data shown represent the mean ± SD from three independent experiments. (D) Western-blot analysis of the expression of Ki-67 in CRBP-1 overexpressed and control PLC/PRF/5 and Huh7 cells. (E) The tumor formation rate of CRBP-1 overexpressed and control PLC/PRF/5 cells inoculated in Balb/c nude mice. (F) The tumor growth curve was shown in CRBP-1 overexpressed PLC/PRF/5 cells and control ones. All data shown represent the mean ± SD from indicated numbers of xenograft tumor. (G) The photograph of xenograft tumors respectively derived from CRBP-1 overexpressed and control PLC/PRF/5 cells inoculated in Balb/c nude mice

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BMC Cancer

ISSN: 1471-2407

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