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Fig. 4 | BMC Cancer

Fig. 4

From: The landscape of coding RNA editing events in pediatric cancer

Fig. 4

Tissue specificity of selected RNA editing events. Plots are shown for selected RNA editing events taken from among the 722 sites identified in the study. Bottom y-axis for each graph represents the RNA editing VAF for the variant noted. Each point represents one cancer or normal sample, and horizontal black bars represent the median for each cancer or normal tissue type. The top portion of each graph indicates the percentage of samples in which the editing site is expressed (“% expr”) with at least 10 reads of sequencing coverage. VAFs are only shown in the bottom panels for samples meeting this criterion. Samples are divided into cancer (c) or normal (n) tissue types as in Fig. 3 (see Supplementary Table 6 for cancer type abbreviation definitions). The RNA editing site is shown at the top-right of each graph, expressed as the gene and amino acid change caused by the editing event. Each panel highlights an editing event with a specific pattern of interest, including (A) a ubiquitously edited site, (B) a site both edited and expressed primarily in blood cells, (C and D) sites both expressed and edited preferentially in the brain, (E) sites with ubiquitous expression and editing enrichment in brain, (F) a brain-enriched editing site not reported in RADAR, DARNED, or REDIportal, unlike the others in this figure, and (G) a site edited preferentially in solid and brain tissue but not edited in most blood tissues

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