Skip to main content
Fig. 5 | BMC Cancer

Fig. 5

From: Tumor response as defined by iRECIST in gastrointestinal malignancies treated with PD-1 and PD-L1 inhibitors and correlation with survival

Fig. 5

Patients with measurable lesions showing pseudoprogression in terms of tumor diameter. (A) The spider plot of tumor diameter changes showing 2 patients with pseudoprogression. The tumor diameter of both 2 patients increased by more than 40% from baseline and then gradually decreased in the subsequent follow-up. The tumor diameter decreased by more than 30% compared to the peak. (B) A 35-year-old male with advanced rectal cancer with pseudoprogression, corresponding to the green line in (A). A baseline CT scan showed the measuring 10 mm in the short diameter of the left aortic lymph nodes of the abdominal aorta (i, arrow). On the 1st day and at 8 days, the diameter of the lesion (36 mm) increased significantly. A newly enlarged lymph node on the right side of the abdominal aorta, with a short diameter measuring 20 mm (ii); 2nd follow-up scans at 4 months (iii) showing that the left aortic lymph nodes of the abdominal aorta were significantly reduced (11 mm). The abdominal aortic right para-lymph node disappeared. At the 3rd follow-up scan at 11 months (iv), the left aortic lymph nodes of the abdominal aorta were still smaller than before, and the measured value of the short diameter was < 5 mm. Since then, the left aortic lymph nodes of the abdominal aorta still had a short diameter of < 5 mm and a maintained durable response

Back to article page