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Table 2 Clinical responses of third-generation EGFR-TKI as second line therapy in NSCLC patients with EGFR 19delins and EGFR 19del

From: Patients harboring uncommon EGFR exon 19 deletion-insertion mutations respond well to first-generation EGFR inhibitors and osimeritinib upon acquisition of T790M

 

19delins (n = 8)

19del (n = 10)

P value

ORR, n (%)

5 (62.5)

3 (30.0)

0.34

DCR, n (%)

8 (100.0)

8 (80.0)

0.48

Best objective response, n (%)

 CR

0

0

 

 PR

5 (62.5)

3 (30.0)

 

 SD

3 (37.5)

5 (50.0)

 

 PD

0

2 (20.0)

 
  1. CR Complete response, PR Partial response, SD Stable disease, PD Progressive disease, ORR Objective response rate, DCR Disease control rate