| |
Characteristics
|
19delins (n = 41)
|
19del (n = 41)
|
P value
|
|---|
|
Age, years
|
Median (range)
|
60 (30–75)
|
60 (34–76)
|
0.638
|
|
Sex
|
Male
|
17
|
11
|
0.162
|
|
Female
|
24
|
30
| |
|
Smoking status
|
Never
|
34
|
34
|
1.000
|
|
Smoker
|
7
|
7
| |
|
Histological type
|
Adenocarcinoma
|
40
|
41
|
1.000
|
|
Squamous carcinoma
|
1
|
0
| |
|
TNM stage
|
IIIB
|
0
|
0
|
1.000
|
|
IV
|
41
|
41
| |
|
ECOG PFS score
|
0 or 1
|
34
|
31
|
0.414
|
|
2
|
7
|
10
| |
|
Brain metastases
|
No
|
25
|
27
|
0.647
|
|
Yes
|
16
|
14
| |
|
EGFR 19delins variants
|
p.L747_P753delinsS
|
10
| | |
|
p.L747_A750delinsP
|
9
| | |
|
p.L747_T751delinsP
|
6
| | |
|
p.E746_S752delinsV
|
3
| | |
|
Other EGFR 19delins
|
13
| | |
|
EGFR 19del variants
|
p.E746_A750del
| |
36
| |
|
p.L747_S752del
| |
3
| |
|
P.L747_T751del
| |
2
| |
|
First-line treatment
|
Gefitinib
|
24
|
25
|
0.973
|
|
Icotinib
|
15
|
14
| |
|
Erlotinib
|
2
|
2
| |
- 19delins, EGFR exon 19 deletion-insertion; 19del, EGFR exon 19 deletion; ECOG PS Eastern Cooperative Oncology Group performance status
