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Table 2 Univariate and multivariate analyses for survival outcomes in study population

From: Survival impact of additional chemotherapy after adjuvant concurrent chemoradiation in patients with early cervical cancer who underwent radical hysterectomy

Characteristics

 

(A) Disease-free survival

(B) Overall survival

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

HR

95% CI

P

aHR

95% CI

P

HR

95% CI

P

aHR

95% CI

P

Histology

Non-SCC vs. SCC

2.200

1.075–4.505

0.031

2.647

1.253–5.590

0.011

2.403

0.747–7.732

0.142

2.186

0.663–7.215

0.199

2009 FIGO stage

IIA vs. IB

0.860

0.403–1.835

0.696

   

1.876

0.650–5.416

0.245

   

Para-aortic lymphadenectomy

Yes vs. No

1.090

0.542–2.190

0.809

   

1.394

0.482–4.034

0.540

   

Pathologic cervical tumor size*

≥40 vs. < 40 mm

1.639

0.816–3.295

0.165

1.834

0.899–3.741

0.095

1.544

0.517–4.612

0.437

1.557

0.518–4.679

0.431

Indication for CCRT

High-risk vs. Low-risk

2.613

1.014–6.736

0.047

2.741

1.032–7.283

0.043

5.504

0.720–42.091

0.100

4.316

0.547–34.044

0.165

Surgical approach

MIS vs. Open surgery

1.667

0.859–3.239

0.131

2.178

1.079–4.397

0.030

0.798

0.247–2.580

0.706

1.132

0.333–3.850

0.842

Additional chemotherapy

Yes vs. No

1.240

0.624–2.461

0.539

1.149

0.552–2.391

0.710

2.270

0.782–6.584

0.131

1.877

0.621–5.673

0.264

  1. Abbreviations: CCRT concurrent chemoradiation therapy; FIGO International Federation of Gynecology and Obstetrics
  2. *Measured from the uterine specimen