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Fig. 6 | BMC Cancer

Fig. 6

From: Protein deubiquitylase USP3 stabilizes Aurora A to promote proliferation and metastasis of esophageal squamous cell carcinoma

Fig. 6

USP3 promotes proliferation and metastasis of ESCC cells and promotes EMT through Aurora A K143. A-B After knocking down Aurora A with siRNA, USP3 attenuated changed in cell proliferation. C When ECa109 cells overexpressed Aurora A K143R, the cell proliferation rate was accelerated. D-E After overexpression of the Aurora A K143R mutant in ECa109 cells, USP3 reduced the effect on cell proliferation. F-G After overexpression of Aurora A K143R by ECa109 cells, cell invasion and metastasis increased. H-K After overexpression of the Aurora A K143R mutant, USP3 had a reduced effect on cell invasion and metastasis. L-M. mRNA and protein assays demonstrated that Aurora A and Aurora A K143R promoted the EMT process. N-O. After overexpression of the Aurora A K143R mutant, USP3 attenuated changes in the EMT process

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BMC Cancer

ISSN: 1471-2407

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