Table 4 Any Grade of Treatment-Related Adverse Events (TRAEs)
Afatinib (n = 19) | Chemotherapy (n = 89) | p-value | |
|---|---|---|---|
TRAEs | 17 (89.5) | 65 (73.0) | 0.128 |
Skin toxicity (paronychia, rash, acne), n (%) | 17 (89.5) | 5 (5.6) | < 0.001 |
Gastrointestinal toxicity (nausea, vomiting, diarrhea), n (%) | 17 (89.5) | 10 (11.2) | < 0.001 |
Mucositis, n (%) | 4 (21.1) | 10 (11.2) | 0.248 |
Abnormal liver function, n (%) | 0 (0) | 7 (7.9) | 0.206 |
Hematologic toxicity (neutropenia, anemia, thrombocytopenia), n (%) | 1 (5.3) | 61 (68.5) | < 0.001 |
Neuropathy, n (%) | 0 (0) | 15 (16.9) | 0.156 |