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Fig. 8 | BMC Cancer

Fig. 8

From: Dnmt3a is downregulated by Stat5a and mediates G0/G1 arrest by suppressing the miR-17-5p/Cdkn1a axis in Jak2V617F cells

Fig. 8

Dnmt3a regulates the cell cycle of Jak2V617F Baf3 cells through Cdkn1a. A & B. Dnmt3a induced Cdkn1a expression in Jak2V617F BaF3 cells. Full-length blot images are presented in Supplementary Fig. 16 and Supplementary Fig. 17. Inhibitor: LY2784544 incubation. C. Jak2V617F Baf3 cells with Dnmt3a overexpression and with both Dnmt3a overexpression and Cdkn1a knockdown were established. Full-length blot images are presented in Supplementary Fig. 18. D. Cell cycle distribution of wild-type BaF3 cells. E. Cell cycle distribution of Jak2V617F BaF3 cells. F. Cell cycle distribution of Jak2V617F BaF3 cells with Dnmt3a overexpression. G. Cell cycle distribution of Jak2V617F BaF3 cells with both Dnmt3a overexpression and Cdkn1a knockdown. H. Cell cycle distribution statistics of each group of Jak2V617F BaF3 cells

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