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Table 4 FCR-related outcomes

From: Cognitive behavioral therapy for reducing fear of cancer recurrence (FCR) among breast cancer survivors: a systematic review of the literature

Author, Country

FCR Instrument

FCR Variable Type

Assessment Time

Major Findings (Focused on FCR)

Herschbach et al. [23], Germany

FoP-Q-SF

Outcome

Pretest (T0),

posttest (T1),

3-month f/u (T2),

12-month f/u (T3)

There was a significant main effect of time and a significant interaction of group x time. FoP decreased significantly over time in both intervention groups but not in the control group.

van de Wal et al. [24], The Netherlands

CWS

Outcome

Baseline (T0), posttest (T1)

The patients in the bCBT group reported significantly lower CWS and FCRI scores (total score, scores for severity/triggers/distress/functioning impairments) than those in the CAU group.

FCRI: severity, psychological distress, triggers, coping strategies, functioning impairments, insight, & reassurance

Outcome

Baseline (T0), Posttest (T1)

Butow et al. [26], Australia

FCRI: total

Outcome

Baseline (T0), posttest (T1), 3-month f/u (T2), 9-month f/u (T3)

The ConquerFear participants showed greater improvements in FCRI scores than the control participants.

Lengacher et al. [27], USA

CARS: overall fear, problems

Outcome

Baseline (T0), posttest (T1), 3-month f/u (T2)

MBSR(BC) showed significant improvements in FCRs (overall and problems) than UC group at T1 and T2 periods.

Bower et al. [37], USA

QLACS

Outcome

Baseline (T0), posttest (T1), 3-month f/u (T2)

There was no significant group x time interaction effect on FCR at post intervention but there was a significant group difference (group x time interaction) in FCR at the 3-month follow-up.

Johns et al. [38], USA

FCRI: severity, triggers, distress, functioning impairments, insight, reassurance seeking, and coping strategies

Outcome

Baseline (T0), posttest (T1), 1-month f/u (T2), 6-month f/u (T3)

ACT was associated with significant within-group improvements in FCR severity and in the scores for all secondary FCRI subscales except for reassurance seeking and coping across time; between-group differences favored ACT over survivorship education and enhanced usual care, most obviously at T3.

Dodds et al. [39], USA

FCRI: severity, triggers, psychological distress, functioning impairments, and insight domains

Outcome

Baseline (T0), posttest (T1), 1-month f/u (T2)

Compared to the control condition, CBCT was a feasible intervention and was highly satisfactory to BC survivors. Functioning impairments associated with FCR showed a significant changes between pre- and post intervention for the CBCT group.

Gonzalez-Hernandez et al. [40], Spain

FCRI: triggers, psychological stress, coping strategies, and insight

Outcome

Pretest (T0), posttest (T1), f/u (T2)

Psychological stress showed a significant time x group interaction, but there were no significant interaction effects for other factors. Within-group comparisons showed significant pre-to-post and pre-to-follow-up changes in psychological stress for the CBCT group but no significant changes in the TAU group.

Lengacher et al. [41], USA

CARS: overall fear, problems

Mediator

Pretest (T0), posttest (T1)

MBSR(BC) resulted in significant reductions in FCR and improved physical functioning which, in turn, mediated significant reductions in perceived stress and anxiety.

Park et al. [42], Japan

CARS: overall

Outcome

Baseline (T0), posttest (T1), 3-month f/u (T2)

Compared with the control group, the MBCT group showed significant reductions in FCR over time.

Lichtenthal et al. [43], USA

CARS: overall fear, problems (health worries, womanhood worries, role worries, and death worries)

Outcome

Pretest (T0), posttest (T1),

3-month f/u (T2)

Among the subscales, the CARS-Health worries showed a significant time x condition interaction, and there was reliable improvement in health worries from the baseline to the follow-up for the intervention (AIM-FBCR) group.

Tomei et al. [44], Canada

FCRI: total

Outcome

Baseline (T0): control group only, pretest (T1), posttest (T2), 3-month f/u (T3)

There was a significant interaction effect on FCR: the CBT group showed greater reductions in FCR than the control group, and most changes were maintained at the 3-month follow-up.

van Helmondt et al. [45], The Netherlands

FCRI: severity, psychological distress, coping strategies, & functioning impairments

Outcome

Baseline (T0), posttest (T1), 9-month f/u (T2)

There was no effect of CBT-based online self-help training in reducing FCR in breast cancer survivors compared with that of CAU at posttest and 9-month follow-up.

Heinrichs et al. [46], Germany

FoP-Q-SF

Outcome

Pretest (T0),

posttest (T1),

6-month f/u (T2),

12-month f/u (T3)

Patients in the CBT intervention group showed a significantly greater decline in FCR from pre- to post assessment (time x group x sex) than the control group. During long-term follow-up, patients in the control group showed a significant linear decline, while their CBT group counterparts maintained their gains.

Shields et al. [47], USA

CARS: problems (health, womanhood, role, death, and parenting)

Outcome

Baseline (T0), posttest (T1), 1-week f/u (T2), 2-month f/u (T3)

The intervention group showed greater reductions in FCR scores than the control group over time, but the group differences were not statistically significant.

Germino et al. [48], USA

CARS: overall

Outcome

Baseline (T0), 4~6 months postbaseline (T1), 8~10 months postbaseline (T2)

The intervention group had a larger decrease in FCR than the control group, but the result was not statistically significant.

Merckaert et al. [49], Belgium

FCRI: triggers, severity, psychological distress, coping strategies, functioning impairments, insight, and reassurance

Outcome

Pretest (T0), posttest (T1)

Compared with patients in the control group, patients in the CBT group reported greater use of FCR-related coping strategies and greater reduction in FCR-related psychological distress.