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Table 1 Pathologic and clinical data of patients from the Cancer Genome Atlas Project in Cutaneous Melanoma (TCGA-SKCM) according to the APC/CTNNB1 somatic mutation status. Abbreviations: * CTNNB1 copies/mean_cancer_ploidy_rounded_to_nearest_integer

From: The clinical significance of adenomatous polyposis coli (APC) and catenin Beta 1 (CTNNB1) genetic aberrations in patients with melanoma

 

APC/CTNNB1 Mutant

N = 55

APC/CTNNB1 Wild type

N = 415

Age, at specimen procurement (years, median, range)

64 (37, 90)

61 (19, 90)

Breslow Depth, original diagnosis (mm, median, range)

2.85 (0.25, 15)

3 (0, 75)

Ulceration, original diagnosis (percent of specimens %)

39

55

Mitotic count rate, original diagnosis (mitoses/mm2, median, range)

4 (0, 33)

5 (0, 40)

Lymphocyte Score, procured specimen (1+ thru 6+ median, range)

2+ (0,6)

2+ (0, 6)

CTNNB1 gene copies* (median, range)

1 (0.5, 1.5)

1 (0.5, 3)

APC gene copies* (median, range)

1 (0.5, 2.5)

1 (0.33, 2.5)