Table 1 Patient characteristics at time of initial immunotherapy
Pt | Sex | Age range | Site | Mutation | Initial LDH | Metastatic sites | TMB (per Mb) | PDL1 | Brain mets | KPS (%) | Initial CKI | R1 (mo) | CKI toxicity |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | F | 50–60 | Leg | V600E | nl | 2 | NA | NA | + | 90 | P | 4.6 | none |
2 | F | 40–50 | back | V600E | nl | 1 | 3 | 3% | – | 100 | N | 6.8 | none |
3 | M | 20–30 | back | V600E | nl | > 3 | 5 | NA | – | 100 | I/N | 5.1 | fevers, chills, sweats, diarrhea |
4 | M | 60–70 | scalp | V600E | nl | > 3 | NA | 1% | – | 90 | P | 2.8 | headaches, syncope |
5 | M | 30–40 | finger | V600E | nl | 2 | 6 | NA | – | 100 | N | 10.3 | diarrhea |
6 | F | 20–30 | neck | V600E | ↑ | > 3 | NA | NA | + | 90 | I | 1.1 | none |
7 | F | 50–60 | arm | V600E | nl | 1 | 10 | NA | – | 100 | N | 2.8 | rash |
8 | M | 40–50 | ear | V600K | nl | 2 | 25 | NA | – | 90 | I/N | 4.6 | none |
9 | F | 40–50 | arm | V600E | nl | > 3 | NA | NA | – | 100 | I/N | 0.7 | none |
10 | F | 50–60 | leg | V600E | nl | > 3 | NA | NA | – | 90 | I/N | 0.5 | none |
11 | M | 20–30 | leg | V600K | nl | > 3 | NA | NA | – | 100 | N | 2.3 | none |
12 | M | 40–50 | leg | V600E | nl | > 3 | NA | > 1% | – | 90 | I/N | 4.9 | diarrhea, hypopituitarianism, eye pain |
13 | M | 50–60 | leg | V600E | nl | > 3 | NA | 0% | – | 100 | I/N | 0.3 | none |
14 | F | 50–60 | leg | V600E | ↑ | 2 | 5 | NA | – | 100 | N | 14.7 | none |
15 | M | 50–60 | back | V600E | ↑ | > 3 | 8 | NA | + | 80 | I/N | 2.8 | none |
16 | F | 60–70 | back | V600K | nl | 1 | 929 | 0% | – | 90 | I/N | 4.0 | Headaches, fatigue, hypotension, arthralgias, diarrhea |
17 | M | 80–90 | back | V600E | nl | > 3 | NA | 40% | – | 80 | I/N | 0.7 | none |
18 | M | 40–50 | leg | V600K | nl | 1 | NA | NA | – | 90 | P | 3.3 | scalp infection |
19 | M | 60–70 | back | c1794–1796 dup | ↑ | > 3 | NA | NA | + | 80 | I | 0.3 | none |
20 | F | 50–60 | back | V600E | nl | 3 | NA | NA | – | 100 | P | 3.5 | none |
21 | F | 50–60 | chest | V600E | ↑ | > 3 | NA | NA | + | 90 | I/N | 1.4 | none |
22 | M | 50–60 | leg | T599-V600 ins T | nl | 1 | 1 | NA | – | 90 | I/N | 3.5 | none |
23 | M | 30–40 | leg | V600E | nl | > 3 | NA | NA | – | 90 | I/N | 0.5 | diarrhea, nausea, vomiting, abdominal pain, poor appetite |