Table 1 Characteristics of patients with hepatocellular carcinoma by period of diagnosis year
From: Survival improvement and prognosis for hepatocellular carcinoma: analysis of the SEER database
Year of diagnosis | Total | 1988–1992 (n = 2596) | 1993–1997 (n = 4992) | 1998–2002 (n = 10,737) | 2003–2007 (n = 18,387) | 2008–2012 (n = 25,500) | 2013–2015 (n = 18,138) | Ptrend |
|---|---|---|---|---|---|---|---|---|
Age (years)a | 63.1 ± 11.5 | 64.7 ± 12.8 | 64.4 ± 13.0 | 63.0 ± 12.8 | 62.2 ± 12.1 | 62.8 ± 11.0 | 63.9 ± 10.1 | 0.002 |
Age in groups (years) | 0.233 | |||||||
 18–44 | 3205 (4.0) | 203 (7.8) | 388 (7.8) | 663 (6.2) | 853 (4.6) | 730 (2.9) | 368 (2.0) |  |
 45–54 | 15,033 (18.7) | 324 (12.5) | 754 (15.1) | 2440 (22.7) | 4518 (24.6) | 4722 (18.5) | 2275 (12.5) |  |
 55–64 | 28,020 (34.9) | 641 (24.7) | 1158 (23.2) | 2552 (23.8) | 5562 (30.2) | 10,337 (40.5) | 7770 (42.8) |  |
 65–74 | 19,640 (24.4) | 812 (31.3) | 1540 (30.8) | 2845 (26.5) | 4065 (22.1) | 5504 (21.6) | 4874 (26.9) |  |
  ≥ 75 | 14,449 (18.0) | 616 (23.7) | 1152 (23.1) | 2237 (20.8) | 3389 (18.4) | 4207 (16.5) | 2848 (15.7) |  |
Sex | < 0.001 | |||||||
 Male | 61,525 (76.6) | 1895 (73.0) | 3630 (72.7) | 7973 (74.3) | 14,113 (76.8) | 19,869 (77.9) | 14,045 (77.4) |  |
 Female | 18,822 (23.4) | 701 (27.0) | 1362 (27.3) | 2764 (25.7) | 4274 (23.2) | 5631 (22.1) | 4090 (22.6) |  |
Race | < 0.001 | |||||||
 White | 53,117 (66.1) | 1546 (59.6) | 2884 (57.8) | 6828 (63.6) | 12,117 (65.9) | 17,267 (67.7) | 12,475 (68.8) |  |
 Black | 10,526 (13.1) | 333 (12.8) | 546 (10.9) | 1249 (11.6) | 2338 (12.7) | 3554 (13.9) | 2506 (13.8) |  |
 Other | 16,406 (20.4) | 713 (27.5) | 1555 (31.1) | 2628 (24.5) | 3899 (21.2) | 4587 (18.0) | 3024 (16.7) |  |
Ethnicity | < 0.001 | |||||||
 Hispanic | 15,046 (18.7) | 238 (9.2) | 707 (14.2) | 1810 (16.9) | 3415 (18.6) | 5036 (19.7) | 3840 (21.2) |  |
 Non-Hispanic | 65,301 (81.3) | 2358 (90.8) | 4285 (85.8) | 8927 (83.1) | 14,972 (81.4) | 20,464 (80.3) | 14,295 (78.8) |  |
Marital Statusb | < 0.001 | |||||||
 Married | 41,744 (54.4) | 1643 (65.6) | 2987 (61.4) | 6071 (58.8) | 9886 (55.7) | 12,542 (51.9) | 8615 (50.5) |  |
 Not married | 34,928 (45.6) | 860 (34.4) | 1874 (38.6) | 4258 (41.2) | 7865 (44.3) | 11,634 (48.1) | 8437 (49.5) |  |
 Unknown | 3675 (4.6) | 93 (2.5) | 131 (3.6) | 408 (3.8) | 636 (3.5) | 1324 (5.2) | 1083 (6.0) |  |
SEER Stageb | < 0.001 | |||||||
 Localized | 35,916 (50.8) | 580 (32.5) | 1500 (39.5) | 4033 (45.3) | 8244 (50.5) | 12,346 (53.3) | 9213 (55.1) |  |
 Regional | 22,235 (31.5) | 611 (34.2) | 1288 (33.9) | 2881 (32.4) | 5152 (31.5) | 7177 (31.0) | 5126 (30.6) |  |
 Distant | 12,538 (17.7) | 596 (33.3) | 1008 (26.6) | 1988 (22.3) | 2933 (18.0) | 3630 (15.7) | 2383 (14.3) |  |
 Unstaged | 9658 (12.2) | 809 (31.2) | 1196 (24.0) | 1835 (17.1) | 2058 (11.2) | 2347 (9.2) | 1413 (7.8) |  |
Tumor Size (cm)b | < 0.001 | |||||||
  ≤ 2 | 7393 (12.7) | 68 (7.1) | 134 (5.8) | 601 (9.7) | 1552 (11.8) | 2744 (13.6) | 2294 (15.0) |  |
 2–5 | 23,919 (41.2) | 284 (29.6) | 732 (31.7) | 2265 (36.7) | 5246 (39.9) | 8638 (42.8) | 6754 (44.3) |  |
  > 5 | 26,716 (46.0) | 606 (63.3) | 1444 (62.5) | 3313 (53.6) | 6352 (48.3) | 8793 (53.6) | 6208 (40.7) |  |
 Unknown | 22,319 (27.8) | 1638 (63.1) | 2682 (53.7) | 4558 (42.4) | 5237 (28.5) | 5325 (20.9) | 2879 (15.9) |  |
Tumor Extentb | < 0.001 | |||||||
 Single lesion w/o vascular invasion | 20,295 (34.7) | 206 (19.8) | 662 (26.7) | 2040 (32.1) | 4786 (34.1) | 7240 (35.9) | 5361 (37.2) |  |
 Multiple lesions w/o vascular invasion | 8597 (14.7) | 76 (7.3) | 236 (9.5) | 697 (11.0) | 2077 (14.8) | 3169 (15.7) | 2342 (16.2) |  |
 Lesion(s) w/vascular invasion | 29,572 (50.6) | 757 (72.9) | 1580 (63.8) | 3613 (56.9) | 7162 (51.1) | 9739 (48.3) | 6721 (46.6) |  |
 Unknown | 21,883 (27.2) | 1557 (60.0) | 2514 (50.4) | 4387 (40.9) | 4362 (23.7) | 5352 (21.0) | 3711 (20.5) |  |
Lymph Node Involvementb | < 0.001 | |||||||
 Yes | 5044 (8.6) | 150 (20.8) | 259 (15.8) | 580 (11.6) | 1107 (8.2) | 1709 (7.9) | 1239 (7.7) |  |
 No | 53,422 (91.4) | 570 (79.2) | 1383 (84.2) | 4412 (88.4) | 12,373 (91.8) | 19,829 (92.1) | 14,855 (92.3) |  |
 Unknown | 21,881 (27.3) | 1876 (72.3) | 3350 (67.1) | 5745 (53.5) | 4907 (26.7) | 3962 (15.5) | 2041 (11.3) |  |
Therapyb | 0.001 | |||||||
 No surgery performed | 55,354 (77.0) |  |  | 8645 (81.6) | 13,285 (73.2) | 19,573 (77.6) | 13,851 (77.3) |  |
 Liver-directed therapy | 6764 (9.4) |  |  | 579 (5.5) | 1994 (11.0) | 2273 (9.0) | 1918 (10.7) |  |
 hepatic resection/lobectomy | 5638 (7.8) |  |  | 828 (7.8) | 1473 (8.1) | 1972 (7.8) | 1365 (7.6) |  |
 Hepatectomy with transplant | 4140 (5.8) |  |  | 547 (5.2) | 1394 (7.7) | 1410 (5.6) | 789 (4.4) |  |
 Unknown | 8451 (10.5) | 2596c | 4992c | 138 (1.3) | 241 (1.3) | 272 (1.1) | 212 (1.2) |  |